Beilstein J. Org. Chem.2009,5, No. 74, doi:10.3762/bjoc.5.74
. Although, the computed energy difference between the most stable conformation anti-11 and the next higher energy conformation syn-anti-11 is only 2.98 kJ/mol, it is intriguing that 11 does not exhibit thia-bridge inversion even at elevated temperatures.
Keywords: conformationalenergyminimization; [3.3